Recombinant human CD10/Neprilysin protein fragment (amino acids 500-750) was used as the immunogen for the recombinant MME antibody.
Recognizes a 100kDa glycoprotein, identified as CD10, also known as Membrane Metalloendopeptidase (MME), Common Acute Lymphocytic Leukemia Antigen (CALLA) and Neprilysin. It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt s, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue.CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.
