Human papilloma virus type 16, major capsid protein L1, was used as the immunogen for the HPV-16 L1 antibody.
Infection with specific types of HPV has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are strongly associated with cervical, vaginal, and vulvar malignancies.