C-terminal-binding protein 2 Antibody / CTBP2, Clone: [PCRP-CTBP2-2D11], Mouse, Monoclonal
Artikelnummer:
NSJ-V9186-100UG
Hersteller Artikelnummer:
V9186-100UG
Alternativnummer:
NSJ-V9186-100UG
Hersteller:
NSJ Bioreagents
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FACS, IF
Spezies Reaktivität:
Human
Immunogen:
Recombinant full-length human CTBP2/C-terminal-binding protein 2 protein was used as the immunogen for the C-terminal-binding protein 2 antibody.
The gene CTBP2 (C-terminal binding protein 2) encodes a member of the CtBP-family. The gene is mapped to human chromosome 21q21.3. It is found to be expressed ubiquitously, with higher expression in the heart, skeletal muscle, and pancreas. The gene CTBP2 (C-terminal binding protein 2) encodes a protein that functions as a transcriptional co-repressor of several tumor suppressor genes resulting in enhanced cancer cell migration and invasion. Its expression is found to be upregulated in hepatocellular carcinoma (HCC). It may be a potential prognostic marker for post liver resection HCC. It is involved in several types of tumor initiation, progression and response to therapy. It is found to interact with the C-terminal region of adenovirus type 2/5 E1A protein, a region that negatively regulates tumorigenicity and the extent of oncogenic transformation.
