CD325 Antibody / CDH2 / N-Cadherin, Clone: [MNCD2], Rat, Monoclonal
Artikelnummer:
NSJ-V9199-20UG
Hersteller Artikelnummer:
V9199-20UG
Alternativnummer:
NSJ-V9199-20UG
Hersteller:
NSJ Bioreagents
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
IHC-P
Spezies Reaktivität:
Human, Mouse
Immunogen:
A portion of amino acids 308-597 was used as the immunogen for the CD325 antibody.
Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.
