40S Ribosomal protein SA Antibody / RPSA / Laminin Receptor 1, Clone: [RPSA/6332R], Rabbit, Monoclonal
Artikelnummer:
NSJ-V9408-20UG
Hersteller Artikelnummer:
V9408-20UG
Alternativnummer:
NSJ-V9408-20UG
Hersteller:
NSJ Bioreagents
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC-P
Spezies Reaktivität:
Human
Immunogen:
Recombinant full-length human RPSA protein was used as the immunogen for the 40S Ribosomal protein SA antibody.
Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family member, 40S Ribosomal protein SA, also called Laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype.
