This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 11-24 of Human CAND1/TIP120A (N-terminal) coupled to KLH.
Konjugation:
Unconjugated
Alternative Synonym:
rabbit anti-CAND1 antibody, Cullin associated NEDD8 dissociated protein 1 antibody, p120 CAND1 antibody, TATA binding protein interacting protein, 20A antibody, TBP interacting protein antibody, TBP interacting protein of 120 kDa A antibody, TIP120 antibody
ELISA: 1:2,000 - 1:10,000, IHC: User Optimized, IP: User Optimized, WB: 1:500 - 1:1,000
Anwendungsbeschreibung:
This antibody reacts with human, rat, and mouse CAND1 tested by western blot and immunoprecipitation. The antibody immunoprecipitates in vitro translated protein and protein from cell lysates (using HeLa and NIH-3T3, and others). Coimmunoprecipitation of
Most modifiers mature by proteolytic processing from inactive precursors (a, amino acid). Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin-2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination. In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked head-to-tail. Whether HUB1 functions as a modifier is currently unclear. APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S.Jentsch.
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