WM3702 is a metastatic human melanoma cell line that displays pigmented, thin elongated morphology in culture. This cell line was established from a right upper flank of back in a 58-year-old male with necrotic fungating melanoma. The subject displayed metastatic melanoma forming multiple subcutaneous nodules with overlying skin ulcerations. This cell line contains a Q61L mutation at position 61 in the N-RAS gene. The Q61L mutation results in an amino acid substitution at position 61 in NRAS, from a glutamine (Q) to a leucine (L). WM3702 cells match with WM3758 and WM3682. These cells produce xenograft tumors when injected into immunocompromised mice.
Konzentration:
1.0 million cells/mL (Count By Hemocytometer)
Puffer:
None
Quelle:
Human
Formulierung:
Frozen Cell Suspension
Anwendungsbeschreibung:
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Human melanoma tumor cells with known gene mutations, disease stage, STR, and RPPA profiling
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