WM983B is a human metastatic melanoma cell line that was established from an inguinal node metastatic site in a 54-year-old male patient. The subject displayed malignant melanoma of polypoid type, level IV with a tumor thickness of 2.5 cm. MW983B line contains the BRAF V600E mutation that causes increased signaling via the extracellular signal-regulated MAPK/ERK kinase pathways to enhance proliferation. WM983B is wild type for PTEN, N-ras, c-KIT, and CDK4. This cell line was derived from the same patient as the cell lines WM983A, WM983B BR, and WM983C. WM983B cells produce xenograft tumors when injected into immunocompromised mice.
Konzentration:
1.0 million cells/mL (Count By Hemocytometer)
Puffer:
None
Quelle:
Human
Formulierung:
Frozen Cell Suspension
Anwendungsbeschreibung:
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Human melanoma tumor cells with known gene mutations, disease stage, STR, and RPPA profiling
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