Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.
Molekulargewicht:
882.42
Reinheit:
97.14%
CAS Nummer:
[2180923-05-9]
Formel:
C45H48ClN7O8S
Target-Kategorie:
Bcl-2 Family
T10483
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