CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective, with higher selectivity for VEGFR2 and bFGF than for EGFR, PDGFRbeta and related tyrosine kinases (TKs). PDGFRbeta and related tyrosine kinases (TKs) CP-547632 has antitumour activity.
Molekulargewicht:
532.4
Reinheit:
0.9939
CAS Nummer:
[252003-65-9]
Formel:
C20H24BrF2N5O3S
Target-Kategorie:
PDGFR|||FGFR|||VEGFR|||BTK
T10870L
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