CP5V is a rationally designed PROTAC molecule composed of ligands for von Hippel-Lindau and cyclin-dependent kinase, which selectively induces degradation of Cdc20 by tethering it to the VHL/VBC E3 ligase complex, leading to ubiquitination and proteasomal degradation, mitotic arrest, and suppression of cancer cell proliferation, thereby serving as a mechanistic tool for cell cycle and oncology research.
Molekulargewicht:
1075.49
CAS Nummer:
[2509359-75-3]
Formel:
C46H66Cl3N9O12S
Target-Kategorie:
APC/C|||PROTACs
T10875
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