CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer [1].
Molekulargewicht:
291.69
Reinheit:
0.9959
CAS Nummer:
[1353749-74-2]
Formel:
C10H14ClN3O5
Target-Kategorie:
Apoptosis|||Androgen Receptor
T10896L
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten