GCN2-IN-6 is a potent and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50: 1.8 nM) and cellular assays (IC50: 9.3 nM). GCN2-IN-6 is also an eIF2alpha kinase PERK inhibitor with IC50s of 0.26 nM in enzymatic assay and 230 nM in cells respectively.
Molekulargewicht:
485.29
Reinheit:
0.98
CAS Nummer:
[2183470-09-7]
Formel:
C19H12Cl2F2N4O3S
Target-Kategorie:
PERK
T11374
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