ICA-105665 (PF-04895162) is a potent and orally active opener of neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels. ICA-105665 had low cytotoxic potential in human hepatocytes but inhibited liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 µM). ICA-105665 can penetrate the central nervous system (CNS) and has antiseizure effects [1][2][3][4].
Molekulargewicht:
355.34
CAS Nummer:
[2694728-63-5]
Formel:
C19H15F2N3O2
Target-Kategorie:
Others|||Potassium Channel
T11606
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