KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor, with IC50 values of 71 nM, 19 nM, 69 nM, and 69 nM for KDM5A, KDM5B, KDM5C, and KDM5D, respectively. Multiple myeloma MM1S cells treated with KDOAM-25 citrate show increased global H3K4 methylation at transcriptional start sites and impaired proliferation [1].
Molekulargewicht:
499.51
CAS Nummer:
[2448475-08-7]
Formel:
C21H33N5O9
Target-Kategorie:
Histone Demethylase|||Others
T11750
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