LV-320 is a potent, uncompetitive ATG4B inhibitor with an IC50 of 24.5 µM and a Kd of 16 µM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic, and active in vivo. These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts [1].
Molekulargewicht:
520.11
CAS Nummer:
[2449093-46-1]
Formel:
C29H26ClNO2S2
Target-Kategorie:
Autophagy|||Cysteine Protease
T11896
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten