MK-0343, also known as MRK-409, is a GABAA receptor subtype-selective partial agonist that exhibits non-sedating anxiolytic activity in preclinical species but induces sedation in humans, binding with high affinity to alpha1-, alpha2-, alpha3-, and alpha5-containing human recombinant GABA(A) receptors while demonstrating greater agonist efficacy at alpha3 relative to alpha1 subtypes, thereby providing mechanistic insight into subtype-specific modulation of inhibitory neurotransmission.
Molekulargewicht:
397.38
CAS Nummer:
[233275-76-8]
Formel:
C19H17F2N7O
Target-Kategorie:
GABA Receptor
T16084
T16084
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