MRS 1523 can exert an antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 is an effective and selective adenosine A3 receptor antagonist Ki: 18.9 nM and 113 nM for human and rat A3 receptors, respectively). In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively.
Molekulargewicht:
399.55
CAS Nummer:
[212329-37-8]
Formel:
C23H29NO3S
Target-Kategorie:
Calcium Channel|||Adenosine Receptor|||Others
T16135
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