NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity) commonly used in nitric oxide signaling pathway research. It inhibits sGC activity in mouse cerebellum homogenates and neuronal NO synthase (IC50: 17 nM and 20 nM), inhibits 3-morpholino-sydnonimine (SIN-1)-elicited cyclic GMP formation in human cultured umbilical vein endothelial cells (IC50: 30 nM), and completely inhibits NO-dependent relaxant responses in non-vascular smooth muscle (1 µM). NS-2028 also decreases vascular endothelial growth factor-induced angiogenesis and permeability.
Molekulargewicht:
269.05
Reinheit:
99.44%
CAS Nummer:
[204326-43-2]
Formel:
C9H5BrN2O3
Target-Kategorie:
Guanylate cyclase
T16344
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