Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II.
Molekulargewicht:
240.25
Reinheit:
98.07%
CAS Nummer:
[81267-65-4]
Formel:
C15H12O3
Target-Kategorie:
Caspase|||Apoptosis|||p53|||IAP|||Topoisomerase
T16522
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