PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.
Molekulargewicht:
268.29
Reinheit:
97.80%
CAS Nummer:
[608512-97-6]
Formel:
C13H8N4OS
Target-Kategorie:
Apoptosis|||Others
T16550
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