Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pre-mRNA splicing and inducing necrosis.Pladienolide B possesses antitumor activity and can be used to study leukemia and lymphoid tumors. Pladienolide B has antitumor activity and can be used to study leukemia and lymphoid tumors.
Molekulargewicht:
536.7
Reinheit:
98.27%
CAS Nummer:
[445493-23-2]
Formel:
C30H48O8
Target-Kategorie:
Apoptosis
T16551
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