Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at alpha4beta2 nAChRs (Ki=16 nM). It shows high selectivity for alpha6beta2 and alpha4alpha5beta2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM .
Molekulargewicht:
192.26
CAS Nummer:
[161417-03-4]
Formel:
C11H16N2O
Target-Kategorie:
AChR
T16563
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