Ciglitazone (ADD 3878) is a potent and selective PPARgamma agonist (EC50: 3 µM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF). Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia.
Molekulargewicht:
333.45
Reinheit:
98.23%
CAS Nummer:
[74772-77-3]
Formel:
C18H23NO3S
Target-Kategorie:
Apoptosis|||p38 MAPK|||PPAR
T19710
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
