MMs02943764, a derivative of 1,2,4-triazole, exhibits anticancer activity. This compound demonstrates significant antiproliferative effects across various cancer cell lines. Its structural analog, PAC, shows notable cytotoxicity towards the leukemia cell line K562 (IC50=35.264 µM), functioning by inhibiting Mdm2 and Pirh2 to reduce degradation of p53 and consequently inducing cell cycle arrest in K562 cells.
Molekulargewicht:
551.45
CAS Nummer:
[708287-29-0]
Formel:
C24H25BrF2N4O2S
Target-Kategorie:
MDM-2/p53
T200273
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