LBG20304 (compound 2s) serves as a ligand for the homologous GluK5 receptor, demonstrating an IC50 of 432 nM and exhibiting over 40-fold selectivity against the GluK1-3 isoforms. At concentrations below 10 µM, LBG20304 shows neither agonistic nor antagonistic effects on heterologous GluK2/5 receptors. However, at concentrations above 10 µM, it displays minimal agonist activity in neuronal slices (rat).
Molekulargewicht:
382.37
Formel:
C19H18N4O5
Target-Kategorie:
iGluR
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