COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-kappaB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IkappaB, phosphorylation and nuclear translocation of NF-kappaB p65, and the expression of COX-2 and iNOS.
Target-Kategorie:
NF-kappaB|||NO Synthase|||COX
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