4-C18 EGCG is an effective inhibitor of alpha-amylase and alpha-glucosidase, with IC50 values of 3.74 µM and 0.81 µM respectively. It inhibits carbohydrate-hydrolyzing enzymes, reducing oxidative stress and inflammation, and demonstrates anti-diabetic activity. Additionally, 4-C18 EGCG downregulates pro-inflammatory cytokines and exhibits cytotoxicity at 50 µM in primary human peripheral blood mononuclear cells (PBMC), and non-cancerous cell lines 3T3-L1 and HEK 293.
Target-Kategorie:
Glucosidase
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