Compound 11, a selective PPARdelta agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARdelta receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFalpha and IL-6 in LPS-stimulated RAW264.7 cells via the NF-kappaB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.
Molekulargewicht:
440.46
CAS Nummer:
[2982696-04-6]
Formel:
C19H15F3N2O3S2
Target-Kategorie:
PPAR
T200543
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