DPP-21 is an inhibitor of microtubule protein polymerization (IC50: 2.4 µM). It exhibits antiproliferative activity against various cancer cell lines, with IC50 values of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23), and 9.37 nM (HepG2). DPP-21 induces cell cycle arrest at the G2/M phase of mitosis and subsequently triggers apoptosis in tumor cells by decreasing Bcl-2 while increasing pro-apoptotic protein Bax levels.
Molekulargewicht:
308.4
CAS Nummer:
[2924883-83-8]
Formel:
C17H16N4S
Target-Kategorie:
Apoptosis
T200560
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