Antiproliferative agent-60 (compound 8c), an 11-Azaartemisinin derivative, exhibits outstanding anticancer activity. It demonstrates tumor selectivity up to 32 times higher when compared to normal Hek293 cells. The IC50 values for Antiproliferative agent-60 are 7.7 µM for epidermoid carcinoma (KB), 42.5 µM for HepG2, and 15.5 µM for A549 cells.
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