GK241 (compound 31a-c), a 2-oxoamide-based compound, exhibits inhibitory activity against group IIA secretory phospholipase A2 (GIIA sPLA2) in humans and mice, with IC50 values of 143 nM and 68 nM, respectively. The mechanism of inhibition has been explored through molecular dynamics simulations.
Molekulargewicht:
369.54
CAS Nummer:
[1899930-93-8]
Formel:
C21H39NO4
Target-Kategorie:
Others
T200586
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