LSD1-IN-35 (Compound Z-1) is a selective inhibitor of LSD1, exhibiting an IC50 of 108 nM. This compound inhibits the demethylation of H3K4me1/2 and acts as an immunomodulator. Additionally, LSD1-IN-35 enhances the responsiveness of gastric cancer cells to T-cell killing by reducing PD-L1 expression, thereby weakening the PD-1/PD-L1 interaction.
Molekulargewicht:
446.57
CAS Nummer:
[2992690-04-5]
Formel:
C25H26N4O2S
Target-Kategorie:
PD-1/PD-L1|||Histone Demethylase
T200691
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