D34-919 is a potent inhibitor of the ALDH1A3-PKM2 interaction, effectively inhibiting the ALDH1A3-mediated tetramerization enhancement of PKM2. Treatment mediated by D34-919 both in vitro and in vivo enhances and restores apoptosis and sensitivity in glioblastoma (GBM) cells induced by radiochemotherapy.
Molekulargewicht:
409.55
CAS Nummer:
[1011641-78-3]
Formel:
C22H27N5OS
Target-Kategorie:
Dehydrogenase|||PKM
T201370
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