MG-T-19, a TIM-3 inhibitor (KD=0.26 µM), significantly inhibited the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-alpha and IFN-gamma in PBMCs, which reactivated the tumor-attacking ability of T cells.
Molekulargewicht:
596.6
Reinheit:
98.30%
CAS Nummer:
[328540-44-9]
Formel:
C18H8Br2ClF3N4O2S
Target-Kategorie:
Immunology/Inflammation related
T201721
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