TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 µM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 µM. Additionally, TH023 inhibits the activation of NF-kappaB and reduces the nuclear translocation of NF-kappaB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.
Molekulargewicht:
430.88
Formel:
C22H21ClF2N4O
Target-Kategorie:
NF-kappaB
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
