AChE/BChE-IN-23 (Compound 6e) is a dual inhibitor of acetylcholinesterase and butyrylcholinesterase, exhibiting IC50 values of 0.91 µM for AChE, 1.19 µM for eqBChE, and 1.01 µM for hBChE. This compound also demonstrates antioxidant properties and inhibits the aggregation of Abeta1-42 and Tau proteins. Moreover, AChE/BChE-IN-23 prevents the activation of microglial cells by inhibiting the release of reactive oxygen species and mitochondrial damage. Additionally, it reduces the levels of the NLRP3 inflammasome in human microglial cells and reverses memory impairment in mice induced by scopolamine.
Molekulargewicht:
367.4
Formel:
C19H21N5O3
Target-Kategorie:
Cholinesterase (ChE)|||Cytochromes P450|||NOD-like Receptor (NLR)|||Parasite|||Microtubule Associated|||Mitochondrial Metabolism|||Beta Amyloid|||ROS|||Reactive Oxygen Species
T201792
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