Imarikiren, CAS [[1202265-63-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: Imarikiren, CAS [[1202265-63-1]] Preis auf Anfrage
• Artikelnummer: TGM-T202395
• Hersteller Artikelnummer: T202395
• Alternativnummer: TGM-T202395-10MG,TGM-T202395-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien
• Alternative Synonym: 01IC75R817 , TAK-272 free base, (+)- , TAK-272 free base

Produktbeschreibung

Imarikiren (also known as TAK-272) is a potent, highly selective, orally bioavailable direct renin inhibitor primarily used for treating diabetic nephropathy. In hPRA assays, TAK-272 exhibits strong inhibitory activity against human renin (IC50 = 2.1 nM) and demonstrates excellent selectivity over other aspartic proteases such as pepsin (IC50 > 10 µM) and cathepsin D (IC50 > 10 µM). In rats, TAK-272 shows significantly improved pharmacokinetic properties (F = 25.2%) and, upon oral administration (3 and 10 mg/kg), exhibits a dose-dependent, potent, and sustained antihypertensive effect. Currently, TAK-272 HCl is undergoing human clinical trials.

Produkteigenschaften

• Molekulargewicht: 499.65
• CAS Nummer: [1202265-63-1]
• Formel: C27H41N5O4

Bilder

T202395