GED-0507-34 Levo ((S)-3-(4-Aminophenyl)-2-methoxypropanoic acid), an orally available PPARgamma modulator for amelioration of inflammation-driven intestinal fibrosis, decreased the expression of the pro-fibrotic genes Acta2, COL1a1, and Fn1, reduced the protein levels of alpha-SMA and collagen I-II, the main markers of fibrosis, as well as the major components of the TGFbeta/Smad pathway, and decreased the expression of IL-13, CTGF, TGFB and ACTA1, and inhibited TGF-beta-induced activation of fibroblasts and IECs cell lines.
Molekulargewicht:
195.22
Reinheit:
98.19%
CAS Nummer:
[921195-93-9]
Formel:
C10H13NO3
Target-Kategorie:
PPAR|||Interleukin|||TGF-beta/Smad
T202784
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