MU1210 (compound 12f) acts as an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 with IC50 values of 8, 20, and 12 nM, respectively, and exhibits IC50 values of 187 and 1309 nM for HIPK1 and DYRK2. Additionally, MU1210 demonstrates favorable pharmacokinetic properties in mice (10 mg/kg, intraperitoneal injection: Cmax=1.24 µM, T1/2=58 minutes, no acute toxicity observed).
Molekulargewicht:
352.39
CAS Nummer:
[2275601-87-9]
Formel:
C22H16N4O
Target-Kategorie:
DYRK|||CDK
T203034
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