LW1564 is an HIF-1alpha inhibitor with an IC50 of 1.2 µM in HepG2 cells. It suppresses mitochondrial respiration, reduces ATP production, and stimulates HIF-1alpha degradation, thereby inhibiting the proliferation of various cancer cells with a GI50 ranging from 0.4 to 4.6 µM. Additionally, LW1564 activates the AMPK signaling pathway and inhibits lipid synthesis. In HepG2 xenograft mouse models, LW1564 demonstrates antitumor activity.
Molekulargewicht:
731.84
CAS Nummer:
[2668337-39-9]
Formel:
C42H48F3N3O5
Target-Kategorie:
AMPK|||HIF/HIF Prolyl-Hydroxylase
T203051
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