MN-25 (compound 4a) is an orally active indole pyridinone that functions as a novel cannabinoid ligand. It exhibits binding affinities (Ki) of 245 nM for CB1 and 11 nM for CB2 receptors. As a CB2 agonist, MN-25 inhibits TNF-R release from human peripheral blood mononuclear cells in vitro, with an IC50 of 33 µM. However, in an acute inflammation model in mice, MN-25 did not demonstrate efficacy at oral doses up to 50 mg/kg.
Molekulargewicht:
439.59
CAS Nummer:
[501926-82-5]
Formel:
C26H37N3O3
Target-Kategorie:
TNF|||Cannabinoid Receptor
T203060
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