EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) (IC50 = 4 µM) and adenosine deaminase (ADA). It exhibits concentration-dependent inhibition of cGMP-stimulated PDE2 activity, with IC50 values of 0.8 µM in humans and 2 µM in porcine myocardium, but shows limited inhibition on unstimulated PDE2. EHNA is involved in modulating various pharmacological responses, such as antiviral, antitumor, and antiarrhythmic effects.
Molekulargewicht:
277.37
CAS Nummer:
[51350-19-7]
Formel:
C14H23N5O
Target-Kategorie:
Influenza Virus|||Adenosine Deaminase|||PDE
T203253
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