HIV-1inhibitor-79 (Compound 3k) is an HIV inhibitor that demonstrates significant inhibitory activity against HIV-1 and its common mutants, with IC50 values of 1.9 nM for HIV-1, K103, 8.7 nM for L100I, and 11 nM for E138K. It exhibits low cytotoxicity and a high selectivity index (CC50 = 21.95 µM, SI = 11478). Additionally, HIV-1inhibitor-79 shows antiviral activity against HIV-2, with an EC50 value of 6.14 µM, and effectively inhibits HIV-1 reverse transcriptase with an IC50 of 25 nM.
Molekulargewicht:
383.41
Formel:
C21H17N7O
Target-Kategorie:
HIV Protease|||Reverse Transcriptase
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