KOR agonist 3 (Compound 5) is an agonist of the kappa opioid receptor (kappaOR) with an EC50 of 0.88 nM. It also exhibits some activation of µOR, with an EC50 of 720 nM. However, KOR agonist 3 does not activate deltaOR at concentrations below 1 µM. Its ability to recruit beta-Arrestin-2 is lower than that of U50488.
Molekulargewicht:
388.46
Formel:
C24H24N2O3
Target-Kategorie:
Opioid Receptor
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