MORF-627 is an orally active selective inhibitor of integrin alphavbeta6 (integrinalphavbeta6), with an IC50 of 9.2 nM as measured in a human serum ligand binding assay. It effectively inhibits alphavbeta6-mediated activation of TGF-beta1 with an IC50 of 2.63 nM and suppresses SMAD2/3 phosphorylation, showing an IC50 of 8.3 nM. Additionally, MORF-627 ameliorates bleomycin-induced pulmonary fibrosis in mice.
Molekulargewicht:
537.67
CAS Nummer:
[2412688-16-3]
Formel:
C31H40FN3O4
Target-Kategorie:
Integrin|||TGF-beta/Smad
T203397
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