BBO-10203 is an orally active small molecule, also designated as Compound 758, that functions as a selective PI3Kalpha-Ras interaction disruptor by binding to the Ras-binding domain of PI3Kalpha. BBO-10203 effectively prevents Ras-PI3Kalpha complex formation, inhibits downstream Akt activation without altering basal PI3Kalpha kinase activity, thereby minimizing risks of hyperglycemia and hyperinsulinemia, and displays selective antitumor activity against KRAS-mutant malignancies, making it an important investigational candidate for targeted cancer therapeutics.
Molekulargewicht:
640.7
Reinheit:
98.62%
CAS Nummer:
[2971769-60-3]
Formel:
C34H30F2N6O3S
Target-Kategorie:
Akt|||PI3K
T203428
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