NZ-804 is an orally active inhibitor of the SARS-CoV-2 main protease (Mpro) with an IC50 of 8.9 nM. It inhibits replication of SARS-CoV-2 in HeLa-hACE2 cells, showing an EC50 of 14 nM. NZ-804 exhibits broad-spectrum antiviral activity against various CoVs and decreases viral replication in mice and hamster models.
Molekulargewicht:
469.56
CAS Nummer:
[2858658-44-1]
Formel:
C27H23N3O3S
Target-Kategorie:
SARS-CoV|||Virus Protease
T203497
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