Sesaminol is an orally active activator of the Nrf2-ARE signaling pathway, promoting the nuclear translocation of Nrf2 and boosting the expression of NQO1 to enhance cellular defense against oxidative stress. It inhibits 6-OHDA-induced ROS production and apoptosis in SH-SY5Y cells. Sesaminol also provides neuroprotective effects against Rotenone-induced Parkinsons disease.
Molekulargewicht:
370.35
CAS Nummer:
[74061-79-3]
Formel:
C20H18O7
Target-Kategorie:
Reactive Oxygen Species|||Nrf2
T203511
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