HPK1-IN-54, CAS [[3048537-48-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: HPK1-IN-54, CAS [[3048537-48-7]] Preis auf Anfrage
• Artikelnummer: TGM-T203580
• Hersteller Artikelnummer: T203580
• Alternativnummer: TGM-T203580-10MG,TGM-T203580-50MG
• Hersteller: TargetMol
• Kategorie: Biochemikalien

Produktbeschreibung

HPK1-IN-54 (Compound 16) is a potent inhibitor of HPK1 (hematopoietic progenitor kinase 1), enhancing T cell activation and proliferation by blocking HPK1 activity to exert antitumor effects. It has an IC50 of 2.67 nM for HPK1, showing excellent selectivity over the MAP4K family (>100-fold) and other selected kinases (>300-fold). HPK1-IN-54 exhibits moderate in vivo clearance and reasonable oral exposure in both mice and rats. Additionally, in the CT26 mouse colon cancer model, HPK1-IN-54 demonstrates significant antitumor activity and shows a synergistic effect when combined with anti-PD-1 therapy. HPK1-IN-54 holds promise for research in the field of immunology.

Produkteigenschaften

• Molekulargewicht: 583.66
• CAS Nummer: [3048537-48-7]
• Formel: C32H34FN7O3
• Target-Kategorie: Others|||MAPK

Bilder

T203580